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Helminth Infections
Lymphatic Filariasis
Lymphatic filariasis is a disease caused by infection with a group of worms called filarial worms. Adult worms live in lymphatic vessels where they block the vessels leading to the disease. One severe, often disfiguring form of the disease is known as elephantiasis. The two species of filarial worms causing lymphatic filariasis are Wuchereria bancrofti and Brugia malayi. It is estimated that worldwide 120 million people are suffering from lymphatic filariasis, with W. bancrofti being responsible for the majority of these infections. Wuchereria bancrofti infection is problematic throughout much of sub-Saharan Africa. This parasite is transmitted from person to person by mosquitos. In the severe form of the disease known as elephantiasis, the skin becomes disfigured with a loss of elasticity. Ultimate extremities may become greatly enlarged leading to gross disfiguration. The lower legs and scrotum are the most commonly affected regions.
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